Substitution at R3 that has a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency Along with the halide analogs (74g–h) exhibiting greatest the potency within the group. Further optimization led to the invention of 74i–j, with 74k as by far the most active compound in https://arthurzukao.bluxeblog.com/63595431/fascination-about-indazole-synthesis