Gastrointestinal (GI): NSAIDs that block COX-one activity have correlations with GI issues as a result of inhibition of the synthesis of gastroprotective agents which include PGE2 together with other prostaglandins. This inhibition leads to diminished mucin output by gastric epithelial cells, considerably less bicarbonate secretion, and fewer epithelial mobile turnover, https://waltere664uol4.p2blogs.com/profile