Merchandise 21C (a 220gr. Hard Forged basic centered LFN) is absolutely the heaviest bullet which can be fired by way of 10MM pistols. With its flat nose, it can penetrate straight and very deeply into muscle mass and bone. Straight line penetration into living tissue will exceed a few ft. https://gatewayammo.com/product/buffalo-bore-ammunition-45-70-government-500-grain-full-metal-jacket-flat-nose-box-of-20/