In light of such observations, sirtuins are recognised as novel regulators of immuno-metabolism in humans. Aside from SIRT1, SIRT2 is recently associated with cytoskeleton reworking and activation of NLRP3 in intracellular pathways[117]. In addition to the activation of innate immunity, the contribution of adaptive immune cells in inducing inflammation is https://www.directivepublications.org/journal-of-diabetology-research/